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U takvim situacijama, odluku o primeni leka Bensedin rastvor za injekciju/infuziju treba doneti za svaki slučaj pojedinačno, nakon pažljive procene potencijalne koristi i rizika lečenja (videti odeljak four.four).Takođe je prijavljena i salivarna hipersekrecija. Potreban je oprez pri započinjanju terapije klozapinom kod pacijenata koji već u